Invention Grant
US07659248B2 Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins
失效
包含组织因子途径抑制蛋白或组织因子途径抑制剂变体蛋白的稳定组合物
- Patent Title: Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins
- Patent Title (中): 包含组织因子途径抑制蛋白或组织因子途径抑制剂变体蛋白的稳定组合物
-
Application No.: US11302208Application Date: 2005-12-14
-
Publication No.: US07659248B2Publication Date: 2010-02-09
- Inventor: Bao-lu Chen , Chin-Yi Huang
- Applicant: Bao-lu Chen , Chin-Yi Huang
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines and Diagnostics
- Current Assignee: Novartis Vaccines and Diagnostics
- Current Assignee Address: US CA Emeryville
- Agent Leslie Fischer
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.
Public/Granted literature
Information query
IPC分类:
