Invention Grant
US07659255B2 Methods of inhibiting glutamate receptors by administering the tripeptide KDI
有权
通过施用三肽KDI来抑制谷氨酸受体的方法
- Patent Title: Methods of inhibiting glutamate receptors by administering the tripeptide KDI
- Patent Title (中): 通过施用三肽KDI来抑制谷氨酸受体的方法
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Application No.: US11127206Application Date: 2005-05-12
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Publication No.: US07659255B2Publication Date: 2010-02-09
- Inventor: Paivi Liesi
- Applicant: Paivi Liesi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FI20012082 20011026
- Main IPC: A61K38/06
- IPC: A61K38/06 ; C07K5/09
Abstract:
The present invention relates to a method of using biologically active peptide compounds comprising the tri-peptide motif KDI derived from the neurite outgrowth-promoting domain of laminin-1 as inhibitors of ionotropic glutamate receptors. The peptide compounds are therefore useful in methods of treating disorders responsive to the blockade of these receptors, such as Alzheimer's disease, Parkinson's disease, ALS or stroke.
Public/Granted literature
- US20050288231A1 Biologically active peptides as glutamate receptor inhibitors Public/Granted day:2005-12-29
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