Invention Grant
- Patent Title: Double-stranded synthetic oligonucleotides useful for inducing apoptosis of osteoclasts for the treatment of osteopenic pathologies
- Patent Title (中): 用于诱导破骨细胞凋亡用于治疗骨质疏松症状的双链合成寡核苷酸
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Application No.: US11910086Application Date: 2006-03-30
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Publication No.: US07659258B2Publication Date: 2010-02-09
- Inventor: Roberto Gambari , Letizia Penolazzi , Roberta Piva
- Applicant: Roberto Gambari , Letizia Penolazzi , Roberta Piva
- Applicant Address: IT Ferrara IT Rovigo
- Assignee: Universita' Degli Studi di Ferrara,Associazione Veneta per la Lotta Alla Talassemia
- Current Assignee: Universita' Degli Studi di Ferrara,Associazione Veneta per la Lotta Alla Talassemia
- Current Assignee Address: IT Ferrara IT Rovigo
- Agency: Sughrue Mion, PLLC
- Priority: ITTO2005A0212 20050331
- International Application: PCT/IB2006/000741 WO 20060330
- International Announcement: WO2006/117600 WO 20061109
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K31/70 ; C12Q1/68 ; C12N5/00
Abstract:
The invention relates to a synthetic double-stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis. The oligonucleotide according to the invention is characterized in that it comprises the sequence 5′-ATTTATTTTCAATACTGACT-3′ (SEQ ID NO: 1) or a fragment or a mutant thereof.
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