Invention Grant
US07659261B2 Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
有权
Combretastatin A-4磷酸酯前药单 - 和二 - 有机胺盐，单 - 和二 - 氨基酸盐，以及单 - 和二 - 氨基酸酯盐
- Patent Title: Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
- Patent Title (中): Combretastatin A-4磷酸酯前药单 - 和二 - 有机胺盐，单 - 和二 - 氨基酸盐，以及单 - 和二 - 氨基酸酯盐
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Application No.: US11366105Application Date: 2006-03-01
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Publication No.: US07659261B2Publication Date: 2010-02-09
- Inventor: John J. Venit , Mandar V. Dali , Manisha M. Dali , Yande Huang , Charles E. Dahlheim , Ravindra W. Tejwani
- Applicant: John J. Venit , Mandar V. Dali , Manisha M. Dali , Yande Huang , Charles E. Dahlheim , Ravindra W. Tejwani
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Co.
- Current Assignee: Bristol-Myers Squibb Co.
- Current Assignee Address: US NJ Princeton
- Agent Karen E. Flick
- Main IPC: A01N57/00
- IPC: A01N57/00 ; C07F9/02
Abstract:
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
Public/Granted literature
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