Invention Grant
- Patent Title: Quinazoline derivatives and their use in the treatment of cancer
- Patent Title (中): 喹唑啉衍生物及其在治疗癌症中的应用
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Application No.: US10555085Application Date: 2004-04-27
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Publication No.: US07659279B2Publication Date: 2010-02-09
- Inventor: Laurent Francois Andre Hennequin , Alleyn Plowright
- Applicant: Laurent Francois Andre Hennequin , Alleyn Plowright
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agency: Morgan, Lewis & Bockius LLP
- Priority: GB0309850.6 20030430
- International Application: PCT/GB2004/001799 WO 20040427
- International Announcement: WO2004/096226 WO 20041111
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/88
Abstract:
The invention concerns quinazoline derivatives of the formula: (I); wherein X1, Q1, Z, R1, R2, Y, a and m are as defined in the description, which are erbB tyrosine kinase inhibitors, particularly EGFR tyrosine kinase inhibitors. Also claimed are processes for their preparation; pharmaceutical compositions containing them; and their use as therapeutic agents in the treatment of erbB tyrosine kinase mediated diseases such as cancer.
Public/Granted literature
- US20060211714A1 Quinazoline derivatives and their use in the treatment of cancer Public/Granted day:2006-09-21
Information query
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