Invention Grant
- Patent Title: Monocyclic anilide spirolactam CGRP receptor antagonists
- Patent Title (中): 单环酰苯胺己内酰胺CGRP受体拮抗剂
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Application No.: US11660821Application Date: 2005-09-06
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Publication No.: US07659300B2Publication Date: 2010-02-09
- Inventor: Ian M. Bell , Craig A. Stump
- Applicant: Ian M. Bell , Craig A. Stump
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent William Krovatin; John C. Todard
- International Application: PCT/US2005/031713 WO 20050906
- International Announcement: WO2006/029153 WO 20060316
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; C07D209/54
Abstract:
The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20090054408A1 Monocyclic anilide spirolactam cgrp receptor antagonists Public/Granted day:2009-02-26
Information query
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