Invention Grant
- Patent Title: Methods and devices for epithelial protection during photodynamic therapy
- Patent Title (中): 光动力治疗期间上皮保护的方法和装置
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Application No.: US10709122Application Date: 2004-04-14
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Publication No.: US07659301B2Publication Date: 2010-02-09
- Inventor: Richard Rox Anderson , Bernhard Ortel , Edwin K. Joe
- Applicant: Richard Rox Anderson , Bernhard Ortel , Edwin K. Joe
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Nutter McClennen & Fish LLP
- Main IPC: A61B8/00
- IPC: A61B8/00 ; A01N43/38 ; A01N37/12 ; A01N37/44 ; A61K31/195 ; C07B47/00 ; C07D487/22 ; C07C229/00 ; A61N5/02 ; A61N1/39
Abstract:
Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
Public/Granted literature
- US20040259855A1 METHODS AND DEVICES FOR EPITHELIAL PROTECTION DURING PHOTODYNAMIC THERAPY Public/Granted day:2004-12-23
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