Invention Grant
US07659387B1 Transgenic mammals introduced a Period 1 promoter that confers rhythmical expression
失效
转基因哺乳动物引入了赋予节奏表达的Period 1启动子
- Patent Title: Transgenic mammals introduced a Period 1 promoter that confers rhythmical expression
- Patent Title (中): 转基因哺乳动物引入了赋予节奏表达的Period 1启动子
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Application No.: US10130659Application Date: 2000-11-17
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Publication No.: US07659387B1Publication Date: 2010-02-09
- Inventor: Hajime Tei , Yoshiyuki Sakaki , Shin Yamazaki , Michikazu Abe , Ri-ichi Takahashi
- Applicant: Hajime Tei , Yoshiyuki Sakaki , Shin Yamazaki , Michikazu Abe , Ri-ichi Takahashi
- Applicant Address: unknown Madison Hall, Charlottesville JP Osaka
- Assignee: University of Virginia,Mitsubishi Pharma Corporation
- Current Assignee: University of Virginia,Mitsubishi Pharma Corporation
- Current Assignee Address: unknown Madison Hall, Charlottesville JP Osaka
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C.
- Agent Ingrid A. Beattie, Esq.; Cynthia Kozakiewicz, Esq.
- International Application: PCT/JP00/08127 WO 20001117
- International Announcement: WO01/36618 WO 20010525
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N5/06 ; C12N5/10 ; A01K62/027
Abstract:
The present invention relates to an isolated Period 1 (Per1) promoter DNA inducing rhythmical expression of a gene operably linked thereto. This invention also provides a DNA comprising a Period 1 promoter DNA and a gene operably linked thereto, the gene being under the regulation of the promoter DNA. The present invention further provides transformants and transgenic mammals into which the DNA has been introduced. The transformants and transgenic mammals are useful in the screening of pharmaceutical drugs against diseases and disorders pertaining to the circadian rhythm.
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