Invention Grant
US07659400B2 Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging
有权
放射性标记的苯甲酰胺类似物，其合成和用于诊断成像
- Patent Title: Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging
- Patent Title (中): 放射性标记的苯甲酰胺类似物，其合成和用于诊断成像
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Application No.: US11757246Application Date: 2007-06-01
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Publication No.: US07659400B2Publication Date: 2010-02-09
- Inventor: Robert H. Mach , Zhude Tu
- Applicant: Robert H. Mach , Zhude Tu
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Agency: Sonnenschein Nath and Rosenthal LLP
- Main IPC: C07D451/00
- IPC: C07D451/00 ; C07D451/14
Abstract:
Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
Public/Granted literature
- US20080107599A1 RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING Public/Granted day:2008-05-08
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