Invention Grant
US07659408B2 Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
失效
吡唑甲酰胺作为11-β-羟基类固醇脱氢酶-1的抑制剂
- Patent Title: Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
- Patent Title (中): 吡唑甲酰胺作为11-β-羟基类固醇脱氢酶-1的抑制剂
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Application No.: US10567141Application Date: 2004-08-03
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Publication No.: US07659408B2Publication Date: 2010-02-09
- Inventor: Ying-Duo Gao , Xin Gu , Nancy J. Kevin , Sherman T. Waddell
- Applicant: Ying-Duo Gao , Xin Gu , Nancy J. Kevin , Sherman T. Waddell
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dhome Corp.
- Current Assignee: Merck Sharp & Dhome Corp.
- Current Assignee Address: US NJ Rahway
- Agent Mark R. Daniel; Heidi M. Struse
- International Application: PCT/US2004/025036 WO 20040803
- International Announcement: WO2005/016877 WO 20050224
- Main IPC: A61K31/4155
- IPC: A61K31/4155 ; A61K31/4525 ; C07D231/16 ; C07D401/06 ; C07D403/06
Abstract:
Pyrazole carboxamides of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.
Public/Granted literature
- US20080153893A1 Pyrazole Carboxamides as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 Public/Granted day:2008-06-26
Information query
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