Invention Grant
- Patent Title: Process for the allylation of n-acylhydrazones
- Patent Title (中): N-酰基腙的烯丙基化方法
-
Application No.: US10591094Application Date: 2005-02-24
-
Publication No.: US07659424B2Publication Date: 2010-02-09
- Inventor: Shu Kobayashi , Masaharu Sugiura
- Applicant: Shu Kobayashi , Masaharu Sugiura
- Applicant Address: JP Saitama
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP Saitama
- Agency: Edwards Angel Palmer & Dodge LLP
- Agent Peter F. Corless; Christine C. O'Day
- Priority: JP2004-056877 20040301; JP2004-244685 20040825
- International Application: PCT/JP2005/002981 WO 20050224
- International Announcement: WO2005/082840 WO 20050909
- Main IPC: C07C241/02
- IPC: C07C241/02 ; C07C227/04 ; C07C229/08 ; C07C243/38

Abstract:
[PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.
Public/Granted literature
- US20070142672A1 Process for the allylation of n-acylhydrazones Public/Granted day:2007-06-21
Information query