A method and apparatus for supporting multiple device numbers on point-to-point interconnect upstream ports. In one embodiment, the method includes a downstream component (DC) that performs discovery of internal device components of the DC during initialization of the DC. Subsequent to the discovery of internal devices of the DC, the DC may issue a multiple device number (MDN) request to an upstream component (UC) of the DC. In one embodiment, the MDN request may include an indication that the DC supports a “multiple device number capability,” as well as a quantity of the internal device components of the DC. The DC may receive an acknowledgement MDN from the UC to indicate a quantity of device numbers allocated to the DC. Subsequently, the DC may assign device numbers to the internal device components of the DC according to configuration requests received from the UC. Other embodiments are described and claimed.