A fixing structure of direction switch buttons for a reversible wrench, in which the wrench is equipped with two direction switch buttons on a driving portion of the wrench. The wrench includes button-restricting portions and location-restricting portions relative to the driving portion. The two direction switch buttons can be inserted and arranged inside the driving portion. Moreover, a button-fixing device is provided between the two direction switch buttons, the button-fixing device includes an actuating member and a restoring member. The two ends of the actuating member are wedged into the two direction switch buttons respectively so that the two direction switch buttons are driven simultaneously. The actuating member is able to move elastically between the two direction switch buttons by the restoring member so as to connect the two direction switch buttons elastically.