A needle stick protection device includes a housing and a locking member positioned within the housing to permit the selective locking and releasing of the needle relative to the housing. The device further includes a self-locking member cooperating with an opening in the housing to permanently secure the tip of the needle for disposal. The self-locking member is longitudinal in shape and includes a plurality if spring biased locking tabs along the length thereof. The spring biased locking tabs extend outwardly from the longitudinal axis of the self-locking member; wherein the locking tabs engage inner wall surfaces of the housing in a locked position preventing removal of the self-locking member from the housing and securing the needle tip permanently within the housing.