Invention Grant
US07662360B2 Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds
失效
N-羟基丙基甲基丙烯酰胺 - 甲基丙烯酸酯共聚物与核素活化剂和/或抗癌化合物的结合物
- Patent Title: Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds
- Patent Title (中): N-羟基丙基甲基丙烯酰胺 - 甲基丙烯酸酯共聚物与核素活化剂和/或抗癌化合物的结合物
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Application No.: US10521814Application Date: 2003-07-04
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Publication No.: US07662360B2Publication Date: 2010-02-16
- Inventor: Bipin C. M. Patel
- Applicant: Bipin C. M. Patel
- Applicant Address: GB Guildford
- Assignee: Psimei Pharmaceuticals PLC
- Current Assignee: Psimei Pharmaceuticals PLC
- Current Assignee Address: GB Guildford
- Agency: Rothwell, Figg, Ernst & Manbeck
- Priority: EP02255107 20020722
- International Application: PCT/GB03/02919 WO 20030704
- International Announcement: WO2004/009136 WO 20040129
- Main IPC: A61M36/14
- IPC: A61M36/14 ; A61K51/00
Abstract:
The present invention relates to new anti-cancer compounds and in particular to new compounds for use in nuclide activation therapy, such as neutron capture therapy. Specifically this invention provides a conjugate having the general formula P-(L-NAT)n wherein P represents an N-hydroxypropylmethacrylamide-methacrylate copolymer having a molecular weight of 5-6,000 kDa; NAT represents a nuclide activation therapy agent; L represents a linker moiety capable of linking the polymer to the neutron capture therapy agent; and n represents an integer from 1-1,000.
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