Invention Grant
- Patent Title: Interferon alpha receptor 1 antibodies and their uses
- Patent Title (中): 干扰素α受体1抗体及其用途
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Application No.: US11157494Application Date: 2005-06-20
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Publication No.: US07662381B2Publication Date: 2010-02-16
- Inventor: Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- Applicant: Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Baker Botts L.L.P.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08
Abstract:
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
Public/Granted literature
- US20060029601A1 Interferon alpha receptor 1 antibodies and their uses Public/Granted day:2006-02-09
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