Invention Grant
US07662394B2 Nucleic acids encoding chimeric Flavivirus immunogens comprising the Japanese encephalitis virus (JEV) PRM signal sequence
有权
编码包含日本脑炎病毒（JEV）PRM信号序列的嵌合黄病毒免疫原的核酸
- Patent Title: Nucleic acids encoding chimeric Flavivirus immunogens comprising the Japanese encephalitis virus (JEV) PRM signal sequence
- Patent Title (中): 编码包含日本脑炎病毒（JEV）PRM信号序列的嵌合黄病毒免疫原的核酸
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Application No.: US10500796Application Date: 2002-04-04
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Publication No.: US07662394B2Publication Date: 2010-02-16
- Inventor: Gwong-Jen J. Chang
- Applicant: Gwong-Jen J. Chang
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US02/10764 WO 20020404
- International Announcement: WO02/081754 WO 20021017
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/295
Abstract:
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.
Public/Granted literature
- US20050163804A1 Nucleic acid vaccines for prevention of flavivirus infection Public/Granted day:2005-07-28
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