Invention Grant
US07662574B2 Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion
失效
G蛋白偶联受体及其识别配体在鉴定影响催乳素分泌的化合物中的应用
- Patent Title: Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion
- Patent Title (中): G蛋白偶联受体及其识别配体在鉴定影响催乳素分泌的化合物中的应用
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Application No.: US11701719Application Date: 2007-02-02
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Publication No.: US07662574B2Publication Date: 2010-02-16
- Inventor: Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
- Applicant: Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
- Applicant Address: JP Osaka-Shi
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka-Shi
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent David G. Conlin, Esq.; Kathryn A. Piffat, Esq.
- Priority: JP11-60030 19990308; JP11-106812 19990414; JP11-166672 19990614; JP11-221640 19990804; JP11-259818 19990914; JP10-323759 19991113
- Main IPC: G01N33/567
- IPC: G01N33/567 ; C07K14/705
Abstract:
The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
Public/Granted literature
- US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof Public/Granted day:2007-08-30
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