Invention Grant
US07662596B2 Aldolase, and method for producing optically active IHOG and monatin
失效
醛缩酶，以及用于制备光学活性的IHOG和莫纳甜的方法
- Patent Title: Aldolase, and method for producing optically active IHOG and monatin
- Patent Title (中): 醛缩酶，以及用于制备光学活性的IHOG和莫纳甜的方法
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Application No.: US11953372Application Date: 2007-12-10
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Publication No.: US07662596B2Publication Date: 2010-02-16
- Inventor: Masakazu Sugiyama , Kunihiko Watanabe , Kenichi Mori , Hiroyuki Nozaki
- Applicant: Masakazu Sugiyama , Kunihiko Watanabe , Kenichi Mori , Hiroyuki Nozaki
- Applicant Address: JP Tokyo
- Assignee: Ajinomoto Co., Inc.
- Current Assignee: Ajinomoto Co., Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2004-169188 20040607; JP2004-375769 20041227
- Main IPC: C12P13/04
- IPC: C12P13/04 ; C12P17/10 ; C12N9/10 ; C12N1/21
Abstract:
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
Public/Granted literature
- US20090258403A1 NOVEL ALDOLASE, AND METHOD FOR PRODUCING OPTICALLY ACTIVE IHOG AND MONATIN Public/Granted day:2009-10-15
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