Invention Grant
US07662626B2 Cells and methods for estimation of effects on neurological dysfunction
失效
用于评估对神经功能障碍的影响的细胞和方法
- Patent Title: Cells and methods for estimation of effects on neurological dysfunction
- Patent Title (中): 用于评估对神经功能障碍的影响的细胞和方法
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Application No.: US12143202Application Date: 2008-06-20
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Publication No.: US07662626B2Publication Date: 2010-02-16
- Inventor: Seiko Yoshimura , Eiichi Akahoshi , Mitsuko Ishihara
- Applicant: Seiko Yoshimura , Eiichi Akahoshi , Mitsuko Ishihara
- Applicant Address: JP Tokyo
- Assignee: Kabushiki Kaisha Toshiba
- Current Assignee: Kabushiki Kaisha Toshiba
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2005-157528 20050530
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/08 ; C12N5/10 ; G01N33/574 ; C07H21/02
Abstract:
The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowth of neurites is observed by adding the substance for the aryl hydrocarbon receptor. The invention also provides a method for determining the presence of neurotoxicity of a test substance, a method for acquiring a marker for determining the presence of neurotoxicity of the test substance, a method for acquiring a marker for neurological dysfunction, and a method for determining the effect of the test substance on neurological dysfunction using such cells.
Public/Granted literature
- US20090061474A1 CELLS AND METHODS FOR ESTIMATION OF EFFECTS ON NEUROLOGICAL DYSFUNCTION Public/Granted day:2009-03-05
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