Invention Grant
US07662774B2 Method for using lipoprotein associated coagulation inhibitor to treat sepsis
失效
使用脂蛋白相关凝血抑制剂治疗败血症的方法
- Patent Title: Method for using lipoprotein associated coagulation inhibitor to treat sepsis
- Patent Title (中): 使用脂蛋白相关凝血抑制剂治疗败血症的方法
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Application No.: US10891493Application Date: 2004-07-15
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Publication No.: US07662774B2Publication Date: 2010-02-16
- Inventor: Abla A. Creasey , George J. Broze
- Applicant: Abla A. Creasey , George J. Broze
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agency: Banner & Witcoff, Ltd.
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
A method for prophylactically or therapeutically treating sepsis or septic shock is described, wherein an inhibitor to tissue factor is administered to septic patients. Additionally, a method for treating inflammation is described wherein the inhibitor is administered to patients. This inhibitor is termed lipoprotein associated coagulation inhibitor, or commonly LACI. It is 38 kD and has 276 amino acids. LACI has now been shown to be useful for the treatment of sepsis, septic shock and inflammation.
Public/Granted literature
- US20050181993A1 Method for using lipoprotein associated coagulation inhibitor to treat sepsis Public/Granted day:2005-08-18
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