Invention Grant
- Patent Title: Triazolyl macrocyclic hepatitis C serine protease inhibitors
- Patent Title (中): 三唑基大环丙型肝炎丝氨酸蛋白酶抑制剂
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Application No.: US11835657Application Date: 2007-08-08
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Publication No.: US07662779B2Publication Date: 2010-02-16
- Inventor: Ying Sun , Deqiang Niu , Yat Sun Or , Zhe Wang
- Applicant: Ying Sun , Deqiang Niu , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group P.C.
- Agent Carolyn S. Elmore; Edgar W. Harlan
- Main IPC: A61K38/12
- IPC: A61K38/12 ; C07K5/12
Abstract:
The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.
Public/Granted literature
- US20090047248A1 TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS Public/Granted day:2009-02-19
Information query
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