Invention Grant
- Patent Title: Dolastatin 15 derivatives
- Patent Title (中): Dolastatin 15衍生物
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Application No.: US11406512Application Date: 2006-04-18
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Publication No.: US07662786B2Publication Date: 2010-02-16
- Inventor: Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
- Applicant: Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
- Applicant Address: DE Wiesbaden
- Assignee: Abbott GmbH & Co. KG
- Current Assignee: Abbott GmbH & Co. KG
- Current Assignee Address: DE Wiesbaden
- Agency: Lahive & Cockfield, LLP
- Agent Giulio A. DeConti, Jr.; Brian C. Trinque
- Main IPC: A61K38/00
- IPC: A61K38/00

Abstract:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
Public/Granted literature
- US20060270606A1 Dolastatin 15 derivatives Public/Granted day:2006-11-30
Information query
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