Invention Grant
- Patent Title: DNA enzyme to inhibit plasminogen activator inhibitor-1
- Patent Title (中): DNA酶抑制纤溶酶原激活物抑制剂-1
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Application No.: US10512496Application Date: 2003-04-23
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Publication No.: US07662794B2Publication Date: 2010-02-16
- Inventor: Silviu Itescu
- Applicant: Silviu Itescu
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US03/12767 WO 20030423
- International Announcement: WO03/091456 WO 20031106
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A01N43/04 ; A61K31/70
Abstract:
The present invention provides DNAzymes and ribozymes that specifically cleave PAI-1-encoding mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of PAI-1-encoding mRNA. The invention also provides various methods of inhibiting the expression of PAI-1, and methods of treating diseases by such. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes, antisense oligonucleotides, or other inhibitors of PAI-1 expression as active ingredients.
Public/Granted literature
- US20050148527A1 Dna enzyme to inhibit plasminogen activator inhibitor-1 Public/Granted day:2005-07-07
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