Invention Grant
US07662796B2 Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
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使用反义寡核苷酸或siRNA抑制eIF-5A1的表达
- Patent Title: Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
- Patent Title (中): 使用反义寡核苷酸或siRNA抑制eIF-5A1的表达
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Application No.: US11287460Application Date: 2005-11-28
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Publication No.: US07662796B2Publication Date: 2010-02-16
- Inventor: John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
- Applicant: John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
- Applicant Address: US NJ New Brunswick
- Assignee: Senesco Technologies, Inc.
- Current Assignee: Senesco Technologies, Inc.
- Current Assignee Address: US NJ New Brunswick
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
Public/Granted literature
- US20060178330A1 Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 Public/Granted day:2006-08-10
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