Invention Grant
- Patent Title: Pyrazole derivatives having tyrosine kinase inhibitory activity
- Patent Title (中): 具有酪氨酸激酶抑制活性的吡唑衍生物
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Application No.: US12063020Application Date: 2006-07-24
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Publication No.: US07662827B2Publication Date: 2010-02-16
- Inventor: Guenter Hoelzemann , Helene Crassier , Wilfried Rautenberg
- Applicant: Guenter Hoelzemann , Helene Crassier , Wilfried Rautenberg
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Arent Fox LLP
- Priority: DE102005037499 20050809
- International Application: PCT/EP2006/007245 WO 20060724
- International Announcement: WO2007/017083 WO 20070215
- Main IPC: A61K31/4188
- IPC: A61K31/4188 ; A61K31/4375 ; A61K31/519 ; A61K31/415 ; C07D473/30 ; C07D473/34 ; C07D471/06 ; C07D231/40
Abstract:
Compounds of the formula (I), in which R, X, R1, R2, R3 and R4 have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
Public/Granted literature
- US20080207647A1 Pyrazole Derivatives Having Tyrosine Kinase Activity Public/Granted day:2008-08-28
Information query
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