Invention Grant
- Patent Title: Naphthylene derivatives as cytochrome P450 inhibitors
- Patent Title (中): 萘衍生物作为细胞色素P450抑制剂
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Application No.: US10889520Application Date: 2004-07-12
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Publication No.: US07662844B2Publication Date: 2010-02-16
- Inventor: Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Anne Beck , Arlindo L. Castelhano
- Applicant: Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Anne Beck , Arlindo L. Castelhano
- Applicant Address: US NY Melville
- Assignee: OSI Pharmaceuticals, Inc.
- Current Assignee: OSI Pharmaceuticals, Inc.
- Current Assignee Address: US NY Melville
- Agency: OSI Pharmaceuticals, Inc.
- Agent Michael J. Rafa
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/415 ; C07D231/00 ; C07D233/00
Abstract:
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.
Public/Granted literature
- US20060009645A1 Naphthylene derivatives as cytochrome P450 inhibitors Public/Granted day:2006-01-12
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