Invention Grant
- Patent Title: Use of specific cyklolignans
- Patent Title (中): 使用特定的cyklolignans
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Application No.: US12021578Application Date: 2008-01-29
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Publication No.: US07662851B2Publication Date: 2010-02-16
- Inventor: Olle Larsson , Magnus Axelson
- Applicant: Olle Larsson , Magnus Axelson
- Applicant Address: SE Stockholm
- Assignee: Axelar AB
- Current Assignee: Axelar AB
- Current Assignee Address: SE Stockholm
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: SE0102168 20010619
- Main IPC: A61K31/335
- IPC: A61K31/335 ; C07D307/77 ; C07D317/70

Abstract:
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, atherosclerosis and acromegaly. A preferred compound is picropodophyllin.
Public/Granted literature
- US20080221207A1 USE OF SPECIFIC CYKLOLIGNANS Public/Granted day:2008-09-11
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