Invention Grant
- Patent Title: Compounds and preparations having antiviral effect
- Patent Title (中): 具有抗病毒作用的化合物和制剂
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Application No.: US10557922Application Date: 2003-05-22
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Publication No.: US07662852B2Publication Date: 2010-02-16
- Inventor: Masao Mori , Haruo Saito , Hideo Nemoto , Naoiki Yamamoto , Masao Hattori
- Applicant: Masao Mori , Haruo Saito , Hideo Nemoto , Naoiki Yamamoto , Masao Hattori
- Applicant Address: JP Toyama
- Assignee: Lead Chemical Co., Ltd.
- Current Assignee: Lead Chemical Co., Ltd.
- Current Assignee Address: JP Toyama
- Agency: Oliff & Berridge, PLC
- International Application: PCT/JP03/06422 WO 20030522
- International Announcement: WO2004/103360 WO 20041202
- Main IPC: A01N37/02
- IPC: A01N37/02 ; A61K31/22 ; A23L1/30 ; C07C43/02

Abstract:
An antiviral preparation comprising as an active ingredient, a phorbol derivative of formula 1: wherein is R1 is —(CH2)aX(CH2)bCH3, —(CH2)cX(CH2)dYCH3, —CO(CH2)eCH3 or —(CH2)fCH3 R2 is —CO(CH2)nCH3, R3, R4 and R5 are hydrogen atom, or an aliphatic or aromatic carboxylic acid residue, X and Y are O or S, and each of a-f and n is a number, and having a specific safety index S.I.=CC50/EC50 of 10 or more wherein EC50 means a concentration at which HIV-1 induced cytopathogenic effect (CPE) in MT-4 cell is inhibited by 50%, and CC50 means a concentration at which survival of MT-4 cell in a cell proliferation test is reduced by 50%. These preparations are particularly effective for human immuno-deficiency virus (HIV).
Public/Granted literature
- US20070066684A1 Compounds and preparations having antiviral effect Public/Granted day:2007-03-22
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