Invention Grant
- Patent Title: Molecular determinants of tropism and virulence in enteroviruses
- Patent Title (中): 肠道病毒中向性和毒力的分子决定因素
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Application No.: US10048709Application Date: 2000-07-08
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Publication No.: US07662939B1Publication Date: 2010-02-16
- Inventor: Jose R. Romero , Shelton S. Bradrick , James J. Dunn
- Applicant: Jose R. Romero , Shelton S. Bradrick , James J. Dunn
- Applicant Address: US NE Omaha
- Assignee: Board of Regents of the University of Nebraska
- Current Assignee: Board of Regents of the University of Nebraska
- Current Assignee Address: US NE Omaha
- Agency: Dann, Dorfman, Herrell & Skillman
- Agent Robert C. Netter, Jr.
- International Application: PCT/US00/18681 WO 20000708
- International Announcement: WO01/04136 WO 20010118
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/00 ; C12N7/04 ; C12N7/01
Abstract:
Recombinant enteroviruses for use as vaccines or vectors, which are modified in tropism or virulence, are disclosed. Also disclosed are DNA constructs comprising enterovirus-derived molecular determinants of tropism or virulence for use in targeting genes of interest to specific cells or tissues. The recombinant enteroviruses and DNA constructs comprise molecular determinants of tropism and virulence localized in specific domains of the 5′NTR of the enteroviral genome.
Information query
