Invention Grant
- Patent Title: Process for the preparation of cefoxitin
- Patent Title (中): 头孢西丁的制备方法
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Application No.: US10548888Application Date: 2003-12-31
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Publication No.: US07662955B2Publication Date: 2010-02-16
- Inventor: Pandurang Balwant Deshpande , Bhausaheb Pandharinath Khadangale
- Applicant: Pandurang Balwant Deshpande , Bhausaheb Pandharinath Khadangale
- Applicant Address: IN Chennai
- Assignee: Orchid Chemicals and Pharmaceuticals Ltd.
- Current Assignee: Orchid Chemicals and Pharmaceuticals Ltd.
- Current Assignee Address: IN Chennai
- Agency: Oliff & Berridge, PLC
- Priority: IN236/MAS/2003 20030320
- International Application: PCT/IB03/06239 WO 20031231
- International Announcement: WO2004/083217 WO 20040930
- Main IPC: C07D501/57
- IPC: C07D501/57

Abstract:
A process for the preparation of cefoxitin of formula (I) The process includes treating the compound of formula (II) with a halogenating agent in an organic solvent, followed by treatment with alkali/alkaline earth metal methoxide at a temperature in the range of −100° C. to 0° C. The product formed is then isolated as an organic amine salt of the formula (III), The salt of formula (III) is treated with a base in the presence of solvent at a temperature in the range of −75 to 10° C., the product formed is isolated as an organic amine salt of the formula (IV) The compound of formula (IV) is carbamoylated with isocyanate of formula (V) RNCO (V) in the presence of a solvent at a temperature in the range of −60° C. to 10° C., and isolating to get cefoxitin of the formula (I).
Public/Granted literature
- US20060252928A1 Process for the preparation of cefoxitin Public/Granted day:2006-11-09
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