Invention Grant
US07662974B2 Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same
失效
稠合咪唑化合物的制备方法，稳定形式的重格列烷基试剂及其制备方法
- Patent Title: Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same
- Patent Title (中): 稠合咪唑化合物的制备方法，稳定形式的重格列烷基试剂及其制备方法
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Application No.: US10500999Application Date: 2003-01-09
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Publication No.: US07662974B2Publication Date: 2010-02-16
- Inventor: Jun-ichi Kawakami , Koji Nakamoto , Shigeru Nuwa , Syoji Handa , Shokyo Miki
- Applicant: Jun-ichi Kawakami , Koji Nakamoto , Shigeru Nuwa , Syoji Handa , Shokyo Miki
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent David G. Conlin; Nicholas J. DiCoglie, Jr.
- Priority: JP2002-003821 20020110; JP2002-279438 20020925
- International Application: PCT/JP03/00092 WO 20030109
- International Announcement: WO03/059889 WO 20030724
- Main IPC: C07F3/06
- IPC: C07F3/06
Abstract:
The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I): and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.
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