Systems and methods for retaining a card in an information handling system are disclosed. A retainer for use in an information handling system may include a body, at least one mounting feature coupled to the body, and a retention flange coupled to and protruding from the body. The at least one mounting feature may be configured to couple the retainer to a card. The retention flange may have a top edge configured to engage with a bottom edge of a retention ledge associated with a connector to secure the card to the connector. At a least a portion of the top edge of the retention flange of the retainer may be situated in a substantially non-parallel manner relative to the bottom edge of the retention ledge associated with the connector when the retention flange is engaged with the retention ledge.