A needle is provided, having a closed tip configured to minimize tissue damage from penetration of the needle. The needle includes a tubular side wall defining an internal bore. The needle further includes an end wall angled relative to the needle's longitudinal axis and disposed at the distal end of the needle. The needle defines a distal opening spaced from the closed tip, providing access to the internal bore to facilitate fluid transfer. Preferably, the needle is configured to create a crescent-shaped penetration mark. The number and positioning of openings can be varied across embodiments of the invention, while maintaining a closed tip. For example, in certain embodiments, the needle comprises two distal openings defined by the side wall. A distal opening can also be provided by the end wall singly or in combination with additional distal openings.