A multi-purpose minimally invasive instrument having a small diameter elongated rod with a distal end that receives different interchangeable tools for a variety of uses, and also a handle used by an operator to control the interchangeable tool by manipulating the electricity it receives from a generator. The rod enters a cavity through a very small diameter telescopic port, which provides it with added support during its use. Interchangeable tools comprising imaging/surgical/sensing/electromagnet/radiofrequency/laser/heat-generating probes and/or other devices enter the cavity, supported by an introducer removed after tool attachment, one-at-a-time through a regular-size port that is concurrently used by an endoscope/camera. The instrument is adaptable for therapeutic, investigative, and/or other applications, in any space. An important medical benefit is the usage of many tools simultaneously while employing only one regular-size port and a very small diameter port for each additional tool used, which expedites patient recovery with excellent cosmetic outcome.