Invention Grant
US07666428B2 Recombinant allergen with reduced IgE binding but undiminished T-cell antigenicity
有权
具有降低的IgE结合但未减弱的T细胞抗原性的重组变应原
- Patent Title: Recombinant allergen with reduced IgE binding but undiminished T-cell antigenicity
- Patent Title (中): 具有降低的IgE结合但未减弱的T细胞抗原性的重组变应原
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Application No.: US10490305Application Date: 2002-09-13
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Publication No.: US07666428B2Publication Date: 2010-02-23
- Inventor: Nicole Deweerd , Mohan Bir Singh , Prem L. Bhalla , Ines Swoboda
- Applicant: Nicole Deweerd , Mohan Bir Singh , Prem L. Bhalla , Ines Swoboda
- Applicant Address: AU Parkville, Victoria
- Assignee: The University of Melbourne
- Current Assignee: The University of Melbourne
- Current Assignee Address: AU Parkville, Victoria
- Agency: Arent Fox LLP
- Priority: AUPR7792 20010920
- International Application: PCT/AU02/01261 WO 20020913
- International Announcement: WO03/025009 WO 20030327
- Main IPC: A01N37/18
- IPC: A01N37/18 ; A61K38/00 ; A61K39/00 ; A61K39/35 ; A61K39/36 ; C07K2/00 ; C07K4/00 ; C07K5/00 ; C07K7/00 ; C07K14/00 ; C07K16/00 ; C07K17/00
Abstract:
The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.
Public/Granted literature
- US20050074464A1 Recombinant allergen with reduced ige binding but undiminished t-cell antigenicity Public/Granted day:2005-04-07
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