Invention Grant
- Patent Title: Monomeric self-associating fusion polypeptides and therapeutic uses thereof
- Patent Title (中): 单体自缔合融合多肽及其治疗用途
-
Application No.: US11582929Application Date: 2006-10-18
-
Publication No.: US07666622B2Publication Date: 2010-02-23
- Inventor: Prerna Sharma , Margaret Karow
- Applicant: Prerna Sharma , Margaret Karow
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agent Valeta Gregg, Esq.
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N15/00 ; C12N5/00 ; C07K14/00 ; C07H21/04
Abstract:
Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target ligands include interleukin (IL)-13, IL-1, insulin-like growth factor (IGF)-1 and IGF-2.
Public/Granted literature
- US20070087411A1 Monomeric self-associating fusion polypeptides and therapeutic uses thereof Public/Granted day:2007-04-19
Information query
