Invention Grant
US07666626B2 Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
失效
不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性
- Patent Title: Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
- Patent Title (中): 不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性
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Application No.: US12336995Application Date: 2008-12-17
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Publication No.: US07666626B2Publication Date: 2010-02-23
- Inventor: Bruce A. Green , Gary W. Zlotnick , Leah D. Fletcher , Arnold L. Smith , Thomas J. Reilly
- Applicant: Bruce A. Green , Gary W. Zlotnick , Leah D. Fletcher , Arnold L. Smith , Thomas J. Reilly
- Applicant Address: US NJ Madison US MO Columbia
- Assignee: Wyeth Holdings Corporation,The Curators of the University of Missouri
- Current Assignee: Wyeth Holdings Corporation,The Curators of the University of Missouri
- Current Assignee Address: US NJ Madison US MO Columbia
- Agency: Howson & Howson LLP
- Agent Alan M. Gordon, Esq.
- Main IPC: C12P21/06
- IPC: C12P21/06
Abstract:
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
Public/Granted literature
- US20090148465A1 MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITY Public/Granted day:2009-06-11
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