Invention Grant
US07666627B2 Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
有权
折叠的多结构域丝氨酸蛋白酶的重组催化片段，其制备和用途
- Patent Title: Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
- Patent Title (中): 折叠的多结构域丝氨酸蛋白酶的重组催化片段，其制备和用途
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Application No.: US10636602Application Date: 2003-08-08
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Publication No.: US07666627B2Publication Date: 2010-02-23
- Inventor: Péter Gál , Péter Závodszky , Géza Ambrus-Aikelin , József Kardos
- Applicant: Péter Gál , Péter Závodszky , Géza Ambrus-Aikelin , József Kardos
- Applicant Address: HU Dunakeszi
- Assignee: TargetEx Kft.
- Current Assignee: TargetEx Kft.
- Current Assignee Address: HU Dunakeszi
- Agency: Hahn & Voight PLLC
- Agent Jason D. Voight
- Main IPC: C12N15/62
- IPC: C12N15/62 ; C12N9/64 ; C12N15/70
Abstract:
The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin.The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.
Public/Granted literature
- US20050032157A1 Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof Public/Granted day:2005-02-10
Information query
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