Invention Grant
US07666674B2 Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
有权
使用空间稳定的阳离子脂质体在体内高效地输送CPG寡核苷酸
- Patent Title: Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
- Patent Title (中): 使用空间稳定的阳离子脂质体在体内高效地输送CPG寡核苷酸
-
Application No.: US10484991Application Date: 2002-07-29
-
Publication No.: US07666674B2Publication Date: 2010-02-23
- Inventor: Dennis M. Klinman , Ihsan Gursel , Ken J. Ishii
- Applicant: Dennis M. Klinman , Ihsan Gursel , Ken J. Ishii
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US02/24235 WO 20020729
- International Announcement: WO03/040308 WO 20030515
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; A61K9/127 ; A61K31/70 ; A01N43/04
Abstract:
Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.
Public/Granted literature
- US20050214355A1 Washing and chilling apparatus and method Public/Granted day:2005-09-29
Information query
