Invention Grant
- Patent Title: ABCA1 stabilizer
- Patent Title (中): ABCA1稳定剂
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Application No.: US10586338Application Date: 2004-12-22
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Publication No.: US07666900B2Publication Date: 2010-02-23
- Inventor: Shinji Yokoyama , Maki Tsujita , Reijiro Arakawa , Tomoji Aotsuka
- Applicant: Shinji Yokoyama , Maki Tsujita , Reijiro Arakawa , Tomoji Aotsuka
- Applicant Address: JP Aichi
- Assignee: Hykes Laboratories LLC
- Current Assignee: Hykes Laboratories LLC
- Current Assignee Address: JP Aichi
- Agency: Wenderoth, Lind & Ponack, LLP.
- Priority: JP2204-007955 20040115
- International Application: PCT/JP2004/019717 WO 20041222
- International Announcement: WO2005/067904 WO 20050728
- Main IPC: A01N43/02
- IPC: A01N43/02 ; A61K31/38 ; A01N35/00 ; A61K31/10 ; A01N31/00 ; A01N27/00 ; A61K31/015
Abstract:
To provide a pharmaceutically effective prophylactic/preventive agent for low-HDL cholesterolemia, focusing on an HDL-generating mechanism. The ABCA1 stabilizer of the present invention contains a bisphenol-type compound selected form probucol spiroquinone, probucol diphenoquinone, and probucol bisphenol as an effective ingredient. The ABCA1 stabilizer can continuously and stably express ABCA1 by a mechanism quite different from that of conventional processes, and thus is useful as prophylactic/preventive agent for low-HDL cholesterolemia or arteriosclerosis.
Public/Granted literature
- US20070161702A1 Abca1 stabilizer Public/Granted day:2007-07-12
Information query
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