Invention Grant
- Patent Title: Anti-HIV antibody
- Patent Title (中): 抗HIV抗体
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Application No.: US10582861Application Date: 2004-03-09
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Publication No.: US07667006B2Publication Date: 2010-02-23
- Inventor: Nobuo Sakaguchi , Kazuhiko Kuwahara , Chiemi Minoda
- Applicant: Nobuo Sakaguchi , Kazuhiko Kuwahara , Chiemi Minoda
- Applicant Address: JP Kaminashiki-gun
- Assignee: Kumamoto Technology and Industry Foundation
- Current Assignee: Kumamoto Technology and Industry Foundation
- Current Assignee Address: JP Kaminashiki-gun
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2003-418655 20031216
- International Application: PCT/JP2004/003046 WO 20040309
- International Announcement: WO2005/058963 WO 20050630
- Main IPC: C07K16/08
- IPC: C07K16/08 ; C12P21/08 ; C12Q1/70 ; C12N5/12
Abstract:
The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.
Public/Granted literature
- US20080050365A1 Anti-Hiv Antibody Public/Granted day:2008-02-28
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