Invention Grant
- Patent Title: αvβ3-specific antibodies
- Patent Title (中): αv＆bgr 3个特异性抗体
-
Application No.: US12102818Application Date: 2008-04-14
-
Publication No.: US07667007B2Publication Date: 2010-02-23
- Inventor: William D. Huse , Herren Wu
- Applicant: William D. Huse , Herren Wu
- Applicant Address: US CA San Diego
- Assignee: Applied Molecular Evolution, Inc.
- Current Assignee: Applied Molecular Evolution, Inc.
- Current Assignee Address: US CA San Diego
- Agency: McDermott Will & Emery LLP
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αvβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αvβ3 by contacting αvβ3 with an enhanced LM609 grafted antibody.
Public/Granted literature
- US20090023900A1 Anti-AlphaVBeta3 Recombinant Human Antibodies, Nucleic Acids Encoding Same Public/Granted day:2009-01-22
Information query
