Invention Grant
US07668592B2 Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
有权
电穿孔和电泳系统以及在体内实现细胞分子渗透进入细胞的方法
- Patent Title: Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
- Patent Title (中): 电穿孔和电泳系统以及在体内实现细胞分子渗透进入细胞的方法
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Application No.: US11781619Application Date: 2007-07-23
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Publication No.: US07668592B2Publication Date: 2010-02-23
- Inventor: Richard Heller , Richard Gilbert , Mark J. Jaroszeski , Loree C. Heller , Melinda L. Lucas
- Applicant: Richard Heller , Richard Gilbert , Mark J. Jaroszeski , Loree C. Heller , Melinda L. Lucas
- Applicant Address: US FL Tampa
- Assignee: University of South Florida
- Current Assignee: University of South Florida
- Current Assignee Address: US FL Tampa
- Agency: Smith & Hopen, P.A.
- Agent Molly L. Sauter
- Main IPC: A61N1/30
- IPC: A61N1/30
Abstract:
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
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