Provided is a multi-air conditioner central control system, which shares the physical network and control resources with a multi-air conditioner system so as to control a ventilation system in an integrated manner. The central control system includes a multi-air conditioner system including one or more multi-air conditioners connected to a network for indoor air conditioning, a ventilation system including one or more ventilation devices connected to the network for ventilating indoor air by inhaling and exhausting the indoor air, and a central controller connected with the multi-air conditioner system and the ventilation system for monitoring, in real time, a state of each of the multi-air conditioners and the ventilation devices and controlling an operation thereof.