To eliminate needle-stick risk by encapsulating the needle of a syringe immediately after discharge of syringe contents, the entire syringe is housed in a device comprising a hollow body, a spring and a plunger. The barrel of the syringe is held in the body interior against the force of the spring by latching formations internal to the body. The plunger is hollow to provide a chamber to receive the syringe piston and at least part of the barrel. The plunger has deflectable engagement elements at its forward end so it is pushed into the body, it reliably displaces the syringe piston/rod to discharge the syringe contents via a hollow needle, the elements ultimately being deflected outwards as the contents are fully discharged so as not to impede syringe retraction into the hollow plunger. The plunger also has latch opening projections at its forward end.