Invention Grant
- Patent Title: Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
- Patent Title (中): 用于治疗心血管和外周血管疾病的血栓调节素基因的离体和体内表达
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Application No.: US11464712Application Date: 2006-08-15
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Publication No.: US07670597B2Publication Date: 2010-03-02
- Inventor: Lakshman R. Sehgal , Jonathan Wong
- Applicant: Lakshman R. Sehgal , Jonathan Wong
- Applicant Address: US IL Chicago
- Assignee: Biovec, LLC
- Current Assignee: Biovec, LLC
- Current Assignee Address: US IL Chicago
- Agency: Morris, Manning & Martin, LLP
- Agent Ping Wang
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/235
Abstract:
The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
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