Invention Grant
US07670609B2 Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease
有权
设计用于在感染和疾病的所有生理阶段引起结核分枝杆菌的免疫应答的重组BCG结核病疫苗
- Patent Title: Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease
- Patent Title (中): 设计用于在感染和疾病的所有生理阶段引起结核分枝杆菌的免疫应答的重组BCG结核病疫苗
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Application No.: US11945680Application Date: 2007-11-27
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Publication No.: US07670609B2Publication Date: 2010-03-02
- Inventor: Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
- Applicant: Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
- Applicant Address: US MD Rockville
- Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee Address: US MD Rockville
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K39/095
- IPC: A61K39/095
Abstract:
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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