Invention Grant
- Patent Title: Probe of human papillomavirus and DNA chip comprising the same
- Patent Title (中): 人乳头瘤病毒和包含其的DNA芯片的探针
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Application No.: US11664549Application Date: 2005-03-18
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Publication No.: US07670774B2Publication Date: 2010-03-02
- Inventor: Woo-Chul Moon , Myung-Ryurl Oh , Su-Bin Yim , Tae-Han Eum , Eun-Hae Jung , Jung-Eun Ko , Jae-Han Bae
- Applicant: Woo-Chul Moon , Myung-Ryurl Oh , Su-Bin Yim , Tae-Han Eum , Eun-Hae Jung , Jung-Eun Ko , Jae-Han Bae
- Applicant Address: KR Seoul
- Assignee: Goodgene Inc.
- Current Assignee: Goodgene Inc.
- Current Assignee Address: KR Seoul
- Agency: Osha • Liang LLP
- Priority: KR10-2004-0078685 20041004
- International Application: PCT/KR2005/000775 WO 20050318
- International Announcement: WO2006/038753 WO 20060413
- Main IPC: C12Q1/64
- IPC: C12Q1/64 ; C12M1/00
Abstract:
Oligonucleotide probes for analyzing 40 types of HPV were synthesized, and DNA chips were produced by using the oligonucleotide probes. The synthesis of the oligonucleotide probes is based on clones of L1 and E6/E7 genes of 35 types of HPV obtained from cervical cell specimens from 4,898 Korean adult women and tissue specimens from 68 cervical cancer cases in addition to information based on American and European cases. The DNA chips can analyze the 40 types of HPV found in cervical, diagnose complex infection by at least one type of HPV, and have excellent diagnostic sensitivity and specificity on HPV genetic type up to 100% and reproducibility. Also, the DAN chips are superior to conventional analytic method, and very economical, since they can analyze numerous specimens in shortest time. Accordingly, the DNA chips are useful for predicting cervical cancer and precancerous lesion.
Public/Granted literature
- US20070248968A1 Probe of Human Papillomavirus and Dna Chip Comprising the Same Public/Granted day:2007-10-25
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