Invention Grant
US07670805B2 Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
有权
用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原
- Patent Title: Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
- Patent Title (中): 用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原
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Application No.: US12286620Application Date: 2008-10-01
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Publication No.: US07670805B2Publication Date: 2010-03-02
- Inventor: Richard J. Zahradnik , Jeffrey R. Lavigne
- Applicant: Richard J. Zahradnik , Jeffrey R. Lavigne
- Applicant Address: US CA San Clemente
- Assignee: Immutopics, Inc.
- Current Assignee: Immutopics, Inc.
- Current Assignee Address: US CA San Clemente
- Agency: Stetina Brunda Garred & Brucker
- Main IPC: G01N33/531
- IPC: G01N33/531 ; G01N33/532 ; G01N33/533 ; G01N33/534 ; G01N33/535 ; A61K38/10 ; A61K38/22 ; C07K16/06 ; C07K16/26
Abstract:
Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
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